Tyrosinase is a copper-binding enzyme involved in melanin biosynthesis.However, the detailed structure of human tyrosinase has not yet been solved, along with the identification of the key sites responsible for its catalytic activity.We used site-directed mutagenesis to identify the residues critical for the copper binding of human tyrosinase.Seven
Increasing pressures on land resources requires increased land use efficiency.Over 900 million ha of sandy soils throughout the world are extensively used for agricultural crop production, most requiring nutrient inputs.Although use of humic substances together with inorganic fertilizer as soil amendments has been introduced, their synergistic effe
Acute myocardial infarction (MI) is a prevalent and highly fatal global disease.Despite significant reduction in mortality rates with standard treatment regimens, the risk of heart failure (HF) remains high, necessitating innovative approaches to protect final audio sonorous vi cardiac function and prevent HF progression.Cardiac resident macrophage
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